Kinetics of hemin distribution in plasma reveals its role in lipoprotein oxidation.

@article{Miller1999KineticsOH,
  title={Kinetics of hemin distribution in plasma reveals its role in lipoprotein oxidation.},
  author={Yury I. Miller and Nurith Shaklai},
  journal={Biochimica et biophysica acta},
  year={1999},
  volume={1454 2},
  pages={153-64}
}
Hemin is a powerful in vitro inducer of low-density lipoprotein (LDL) oxidation, implicated in development of atherosclerosis. To support the proposed role of hemin in atherogenesis, the question of whether hemin has any chance of getting together with LDL in vivo, must be addressed. A stopped-flow technique was employed in order to investigate the fast kinetics of hemin binding to LDL and to other plasma hemin-binding proteins: high-density lipoprotein (HDL), albumin and hemopexin. Based on… CONTINUE READING

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