Kinetics of finite dose absorption through skin 1. Vanillylnonanamide.

  title={Kinetics of finite dose absorption through skin 1. Vanillylnonanamide.},
  author={Gerald B Kasting},
  journal={Journal of pharmaceutical sciences},
  volume={90 2},
Despite the considerable success in predicting the steady-state dermal absorption rates of chemical compounds from large reservoirs applied to skin, correspondingly little progress has been made in predicting the absorption rate and extent for small doses of topically applied compounds. In the latter case, steady-state absorption rates are generally not obtained, and rapid evaporation or penetration of the dose solvent makes application of permeability coefficient models problematic. This… CONTINUE READING