Kinetics of esmolol, an ultra-short-acting beta blocker, and of its major metabolite.

@article{Sum1983KineticsOE,
  title={Kinetics of esmolol, an ultra-short-acting beta blocker, and of its major metabolite.},
  author={C Y Sum and Avraham Yacobi and R Kartzinel and H F Stampfli and Charles S. Davis and Choon Mei Lai},
  journal={Clinical pharmacology and therapeutics},
  year={1983},
  volume={34 4},
  pages={427-34}
}
Esmolol is an ultra-short-acting beta blocker. Its kinetics was studied in eight healthy subjects after continuous intravenous infusion of 400 micrograms/kg/min over 2 hr. The concentrations of esmolol and its major metabolite, 3-[4-(2-hydroxy-3-[isopropylamino]propoxy)phenyl]propionic acid, in blood and urine were determined by gas chromatographic-mass spectrometric assay and HPLC. The distribution and elimination t1/2s of esmolol averaged 2.03 and 9.19 min. The apparent volume of distribution… CONTINUE READING

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