Kinetics of early insulin response by the isolated and perfused rat pancreas. Suggestion for two different actions of glucose on the insulin releasing process.

The permissive action of glucose (or glyceraldelhyde) is necessary to the glucagon induced insulin release. By collecting every 15 seconds the venous effluent of the perfused and isolated rat pancreas it was observed that the insulin response to glucagon (2 microgram/ml) was immediate if the pancreas was preperfused with low concentration of glucose (5 mM… CONTINUE READING