Kinetics of drug-ribosome interactions defines the cidality of macrolide antibiotics.

@article{Svetlov2017KineticsOD,
  title={Kinetics of drug-ribosome interactions defines the cidality of macrolide antibiotics.},
  author={Maxim S Svetlov and Nora V{\'a}zquez-Laslop and Alexander S Mankin},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2017},
  volume={114 52},
  pages={
          13673-13678
        }
}
Antibiotics can cause dormancy (bacteriostasis) or induce death (cidality) of the targeted bacteria. The bactericidal capacity is one of the most important properties of antibacterial agents. However, the understanding of the fundamental differences in the mode of action of bacteriostatic or bactericidal antibiotics, especially those belonging to the same chemical class, is very rudimentary. Here, by examining the activity and binding properties of chemically distinct macrolide inhibitors of… CONTINUE READING

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