Kinetics of drug release from a biodegradable local drug delivery system and its effect on Porphyromonas gingivalis isolates: An in vitro study

@article{Vijayalashmi2013KineticsOD,
  title={Kinetics of drug release from a biodegradable local drug delivery system and its effect on Porphyromonas gingivalis isolates: An in vitro study},
  author={Ranganathan Vijayalashmi and Sabitha Manhalore Ravindranath and Nadathur Doraiswamy Jayakumar and Padmalatha and Sheeja H. Vargheese and Kikkeri Laxminarayana Kumaraswamy},
  journal={Journal of Indian Society of Periodontology},
  year={2013},
  volume={17},
  pages={429 - 434}
}
Background: Conventional anti-microbial therapy largely consisted of systemic administration of various drugs effective against periodontal pathogens, but fraught with several problems. Based on the concept of local drug delivery a bioresorbable device made of pure fibrillar collagen has been developed. The aim of this study was to study the release of Tetracycline from this collagen fiber (Type I collagen) impregnated with Tetracycline and its antibacterial activity against Porphyromonas… 
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