Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats.

@article{Ramzan1986KineticsOD,
  title={Kinetics of drug action in disease states. XVI. Pharmacodynamics of theophylline-induced seizures in rats.},
  author={I M Ramzan and Gerhard Levy},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1986},
  volume={236 3},
  pages={708-13}
}
Seizures, often with fatal outcome, are a manifestation of pronounced theophylline intoxication. The purpose of this investigation was to characterize the relationship between theophylline concentrations and theophylline-induced convulsions and to develop an animal model suitable for exploring conditions that might predispose theophylline-treated individuals to seizures. Female Lewis rats (approximately 170 g) received an i.v. infusion of theophylline (as aminophylline) at one of three… CONTINUE READING
17 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 17 extracted citations

Similar Papers

Loading similar papers…