Kinetics of delayed-type hypersensitivity to tuberculin induced by bacille Calmette-Guérin vaccination in northern Malawi.

@article{Floyd2002KineticsOD,
  title={Kinetics of delayed-type hypersensitivity to tuberculin induced by bacille Calmette-Gu{\'e}rin vaccination in northern Malawi.},
  author={Sian Floyd and Jorg M P{\"o}nnighaus and Lyn Bliss and Prince Nkhosa and Lifted Sichali and Glyn K Msiska and Paul E. M. Fine},
  journal={The Journal of infectious diseases},
  year={2002},
  volume={186 6},
  pages={807-14}
}
During 1986-1989, a bacille Calmette-Guérin (BCG) vaccine trial was carried out in northern Malawi. The effects of age, sex, and prevaccination delayed-type hypersensitivity (DTH) on the time course of the DTH response over 1-36 months after vaccination were studied in 2418 persons. DTH response increased rapidly, to peak at 31-90 days after vaccination, when most persons had a measurable response. This was followed by a marked decline by 181-365 days, particularly in those <15 years old at… CONTINUE READING

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