Kinetics of cytotoxicity induced by immunotoxins. Enhancement by lysosomotropic amines and carboxylic ionophores.

@article{Casellas1984KineticsOC,
  title={Kinetics of cytotoxicity induced by immunotoxins. Enhancement by lysosomotropic amines and carboxylic ionophores.},
  author={Pierre Casellas and Bernard Bourri{\'e} and Piet Gros and Franz K. Jansen},
  journal={The Journal of biological chemistry},
  year={1984},
  volume={259 15},
  pages={9359-64}
}
The kinetics of cytotoxicity induced by ricin and a series of immunotoxins consisting of ricin A-chain coupled to antibodies against cell-surface antigens has been studied. The inhibition of protein synthesis in cells treated with immunotoxins or ricin occurs after a lag period. The rate of protein synthesis decreases according to a mono-exponential… CONTINUE READING