Kinetics of citalopram in man; plasma levels in patients.

  title={Kinetics of citalopram in man; plasma levels in patients.},
  author={K Fredricson Over\o},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  volume={6 3},
1. Citalopram is rapidly absorbed and slowly eliminated in man. The kinetics is linear and characterized by systemic and apparent oral clearance values of 0.4 l/min, a theoretical distribution volume of 14 l/kg and a half-life of 1 1/2 days. 2. The steady state plasma levels in 70 patients range from 95 to 720 nM at doses of 30 to 60 mg and agree well with predicted values. The mean level is 245 nM at the standard dose of 40 mg daily. 3. Inter-individual variation is 7-fold and independent of… CONTINUE READING

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