Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease.

@article{Robbins2006KineticsOC,
  title={Kinetics of cerebral amyloid angiopathy progression in a transgenic mouse model of Alzheimer disease.},
  author={Elissa M Robbins and Rebecca A. Betensky and Sarah B. Domnitz and Susan M Purcell and Monica Garcia-Alloza and Charles Greenberg and George William Rebeck and Bradley T. Hyman and Steven A. Greenberg and Matthew P. Frosch and Brian J. Bacskai},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2006},
  volume={26 2},
  pages={365-71}
}
Cerebral amyloid angiopathy (CAA), the deposition of cerebrovascular beta-amyloid (Abeta) in the walls of arterial vessels, has been implicated in hemorrhagic stroke and is present in most cases of Alzheimer disease. Previous studies of the progression of CAA in humans and animal models have been limited to the comparison of pathological tissue from different brains at single time points. Our objective was to visualize in real time the initiation and progression of CAA in Tg2576 mice by… CONTINUE READING