Kinetics of cell spreading.

  title={Kinetics of cell spreading.},
  author={François Chamaraux and S{\'e}bastien Fache and Franz Bruckert and Bertrand Fourcade},
  journal={Physical review letters},
  volume={94 15},
Cell spreading is a fundamental event where the contact area with a solid substrate increases because of actin polymerization. We propose in this Letter a physical model to study the growth of the contact area with time. This analysis is compared with experimental data using the ameoba Dictyostelium discoideum. Our model couples the stress, which builds up at the margin of the contact area when the cell spreads, to the biochemical processes of actin polymerization. This leads to a scaling… CONTINUE READING