Kinetics of cell death in T lymphocytes genetically modified with two novel suicide fusion genes

@article{Junker2003KineticsOC,
  title={Kinetics of cell death in T lymphocytes genetically modified with two novel suicide fusion genes},
  author={K. W. Junker and Ulrike Koehl and Sharon Zimmerman and Susanne Stein and Dirk Schwabe and Thomas Klingebiel and Manuel Grez},
  journal={Gene Therapy},
  year={2003},
  volume={10},
  pages={1189-1197}
}
Donor lymphocyte infusions (DLI) following allogeneic stem cell transplantation are known to mediate graft-versus-leukemia effect (GVL). A major side effect of these immunotherapies is the development of graft-versus-host diseases (GVHD). One promising approach to prevent GVHD is to genetically modify donor T cells with a suicide mechanism that can be induced in the case of GVHD. Here we report on a retroviral vector containing the death effector domain (DED) of the human Fas-associated protein… CONTINUE READING