Kinetics of cAMP inhibition of DNA synthesis in bovine adrenocortical cells.

@article{Gill1980KineticsOC,
  title={Kinetics of cAMP inhibition of DNA synthesis in bovine adrenocortical cells.},
  author={Gordon N. Gill and Charles R. Ill and R. K. Watson},
  journal={Molecular and cellular endocrinology},
  year={1980},
  volume={19 1},
  pages={113-22}
}
cAMP-treated bovine adrenocortical cells are arrested in the G1 phase of the cell cycle. Removal of serum also arrests bovine adrenocortical cells in G1. In the presence of cAMP, serum and fibroblast growth factor stimulate increases in medium cell volume, but DNA synthesis is not initiated. Under these conditions cAMP increases steroidogenic capacity 7- to 10-fold as assessed by metabolism of pregnenolone to fluorogenic steroids. When the kinetics of entry of cells into S phase are quantitated… CONTINUE READING

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