Kinetics of amphiphile association with two-phase lipid bilayer vesicles.

  title={Kinetics of amphiphile association with two-phase lipid bilayer vesicles.},
  author={Antje Pokorny and Paulo I. F. Almeida and Erich Christiano M Melo and Winchil L. C. Vaz},
  journal={Biophysical journal},
  volume={78 1},
We examined the consequences of membrane heterogeneity for the association of a simple amphiphilic molecule with phospholipid vesicles with solid-liquid and liquid-liquid phase coexistence. To address this problem we studied the association of a single-chain, fluorescent amphiphile with dimyristoylphosphatidylcholine (DMPC) vesicles containing varying amounts of cholesterol. DMPC bilayers containing 15 mol% cholesterol show a region of solid-liquid-ordered (s-l(o)) coexistence below the T(m) of… CONTINUE READING

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