Kinetics of allopurinol and its metabolite oxypurinol after oral administration of allopurinol alone or associated with benzbromarone in man. Simultaneous assay of hypoxanthine and xanthine by gas chromatography‐mass spectrometry

@article{LartigueMattei1991KineticsOA,
  title={Kinetics of allopurinol and its metabolite oxypurinol after oral administration of allopurinol alone or associated with benzbromarone in man. Simultaneous assay of hypoxanthine and xanthine by gas chromatography‐mass spectrometry},
  author={C. Lartigue-Mattei and Jean Louis Chabard and Jean Michel Ristori and Jeanine Bussiere and H. Bargnoux and J. Petit and J. A. Berger},
  journal={Fundamental \& Clinical Pharmacology},
  year={1991},
  volume={5}
}
Summary— Allopurinol, oxypurinol, hypoxanthine and xanthine were assayed simultaneously using a highly specific method combining gas chromatography and mass spectrometry. Two hypo‐uricaemic prescriptions were compared: i) 300 mg of allopurinol (AL); and ii) 100 mg of allopurinol plus 20 mg of benzbromarone (AL + BZB). When administered acutely, their effects on blood uric acid levels were similar. Analysis of the pharmacokinetic parameters of allopurinol and its metabolite after each treatment… 
Clinical Pharmacokinetics and Pharmacodynamics of Allopurinol and Oxypurinol
TLDR
Measurement of plasma concentrations of oxypurinol in selected patients, particularly those with renal impairment, may help to decrease the risk of toxicity and improve the hypouricaemic response.
Pharmacokinetic and Pharmacodynamic Interaction Between Allopurinol and Probenecid in Patients with Gout
TLDR
Coadministration of allopurinol with probenecid had a significantly greater hypouricemic effect than alloporinol alone despite an associated reduction of plasma oxypurinols concentrations.
Pharmacokinetic and Pharmacodynamic Interaction between Allopurinol and Probenecid in Healthy Subjects
TLDR
Coadministration of allopurinol and probenecid to healthy subjects had a greater hypouricaemic effect than either alloporinol or probenacid alone, despite a reduction in plasma oxypurinl concentrations when the drugs were taken concomitantly.
The optimal use of allopurinol: an audit of allopurinol use in South Auckland.
TLDR
There is poor adherence to the current recommended dosing guidelines for allopurinol and Creatinine clearance rather than plasma creatinine needs to be used to predict the dose of allopURinol.
Effects of quercetin on uric acid metabolism
TLDR
Quercetin supplementation can maintain blood uric acid level and blood pressure within a low-risk range and is probably a result of regulated purine metabolism by quercet in, its microbial derivatives and their metabolites.
Normal hypoxanthine and ammonia release from working muscle in partial HPRT deficiency.
TLDR
Partial deficiency of HPRT (EC 2.4.2.8.) is one of the enzyme defects causing hyperuricemia and gout and the reduced activity of the salvage pathway with increased degradation of hypoxanthine and xanthine into uric acid.

References

SHOWING 1-10 OF 16 REFERENCES
Kinetics of allopurinol after single intravenous and oral doses
TLDR
It was concluded that about 10% of the oral dose was not absorbed and that 12% was eliminated by an unknown mechanism, presumably as riboside, in 6 healthy volunteers after a single intravenous or oral dose of allopurinol.
Clinical Pharmacokinetics of Allopurinol
TLDR
The interaction of allopurinol with oral anticoagulants and phenytoin has not been clearly established in clinical practice, and dosages should be adjusted in patients with renal dysfunction.
Bioavailability of allopurinol oral and rectal dosage forms.
The bioavailability of allopurinol from orally administered tablets and rectally administered suppositories is reported. Two types of rectal suppositories (cocoa butter and polyethylene glycol) were
Effect of single oral doses of benzbromarone on serum and urinary uric acid.
TLDR
The data presented favor a protracted trial of benzbromarone in patients with gout and hyperuricemia as the prolonged duration of action up to 48 hours after dosing is advantageous as the drug need be taken only once a day.
[Assay of plasma xanthine and hypoxanthine by coupled gas chromatography-mass spectrometry and sampling problems].
TLDR
This study confirms that EDTA is the most appropriate anticoagulant and shows that an immediate deproteinisation is necessary after separation of the plasma and the cells, in order to prevent any "in vitro" modification of the oxypurines, in particular erythrocyte hypoxanthine.
Rapid esterification for gas chromatography.
THE RENAL EXCRETION OF OXYPURINES.
...
...