Kinetics of airway hyperresponsiveness and airway eosinophilia in BALB/c mice and their modulation by different dexamethasone treatment regimens.

@article{ElHashim2002KineticsOA,
  title={Kinetics of airway hyperresponsiveness and airway eosinophilia in BALB/c mice and their modulation by different dexamethasone treatment regimens.},
  author={Ahmed Z. El-Hashim and Daniel Wyss and Claudia Zuany-Amorim},
  journal={Pulmonary pharmacology & therapeutics},
  year={2002},
  volume={15 5},
  pages={
          467-75
        }
}
The mechanisms of airway hyperresponsiveness (AHR) are still poorly understood. In this study we have established a model of persistent AHR and eosinophilia and evaluated the prophylactic vs. therapeutic effects of dexamethasone on these parameters. Mice were immunised with ovalbumin (OVA) on day 0 and challenged intranasally on days 10, 11, 12 and 13 with OVA or phosphate buffer saline (PBS). Airway responsiveness to methacholine, measured 24-h post multiple intranasal OVA challenges, was… CONTINUE READING