Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis.

@article{Meurs1999KineticsOA,
  title={Kinetics of aggrecanase- and metalloproteinase-induced neoepitopes in various stages of cartilage destruction in murine arthritis.},
  author={Joyce B. J. van Meurs and Peter L. E. M. van Lent and Astrid E M Holthuysen and Irwin I. Singer and Ellen K Bayne and Wim B. van den Berg},
  journal={Arthritis and rheumatism},
  year={1999},
  volume={42 6},
  pages={1128-39}
}
OBJECTIVE Two major cleavage sites, one mediated by metalloproteinases (MMPs) and the other by an as-yet unidentified enzyme termed aggrecanase, have been observed in aggrecan. To learn more about the relative contribution of these enzymes during cartilage degradation, this study assessed the occurrence of both specific neoepitopes in cartilage during murine arthritis and examined the correlation between neoepitope formation and different aspects of cartilage damage. METHODS Reversible… CONTINUE READING

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