Kinetics of a human glutamate transporter

  title={Kinetics of a human glutamate transporter},
  author={Jacques I Wadiche and Jeffrey L. Arriza and Susan Gaye Amara and Michael P. Kavanaugh},
Currents mediated by a glutamate transporter cloned from human motor cortex were measured in Xenopus oocytes. In the absence of glutamate, voltage jumps induced Na(+)-dependent capacitive currents that were blocked by kainate, a competitive transport antagonist. The pre-steady-state currents can be described by an ordered binding model in which a voltage-dependent Na+ binding is followed by a voltage-independent kainate binding. At -80 mV, two charges are translocated per molecule of glutamate… CONTINUE READING
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