Kinetics of T-cell receptor binding by bivalent HLA-DR. Peptide complexes that activate antigen-specific human T-cells.

@article{Appel2000KineticsOT,
  title={Kinetics of T-cell receptor binding by bivalent HLA-DR. Peptide complexes that activate antigen-specific human T-cells.},
  author={Heiner Appel and Laurent Robert Gauthier and Jason W Pyrdol and Kai W Wucherpfennig},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 1},
  pages={312-21}
}
Monovalent major histocompatibility complex-peptide complexes dissociate within seconds from the T-cell receptor (TCR), indicating that dimerization/multimerization may be important during early stages of T-cell activation. Soluble bivalent HLA-DR2.myelin basic protein (MBP) peptide complexes were expressed by replacing the F(ab) arms of an IgG2a antibody with HLA-DR2.MBP peptide complexes. The binding of bivalent HLA-DR2.peptide complexes to recombinant TCR was examined by surface plasmon… CONTINUE READING

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