Kinetics of T cell activation in acute and chronic forms of murine graft-versus-host disease.

@article{Via1991KineticsOT,
  title={Kinetics of T cell activation in acute and chronic forms of murine graft-versus-host disease.},
  author={Charles S. Via},
  journal={Journal of immunology},
  year={1991},
  volume={146 8},
  pages={2603-9}
}
Induction of graft-vs-host disease (GVHD) in the parent-into-F1 model is dependent on the presence of T cells in the donor inoculum. Although in vivo activation of donor T cells in response to F1 alloantigens is thought to be critical to GVHD induction, direct evidence of activated donor T cells has been lacking in this model. In the present study, spleen cells from acute or chronic GVHD mice were studied for evidence of T cell activation at multiple intervals early after GVHD induction. Spleen… CONTINUE READING
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