Kinetics of Linezolid in Continuous Renal Replacement Therapy: An In Vitro Study.

Abstract

BACKGROUND Continuous veno-venous hemofiltration (CVVH) could affect the pharmacokinetic profile of linezolid (LZD). The aim of this study was to evaluate the LZD extracorporeal clearance using an in vitro CVVH model. METHODS A sham miniaturized CVVH circuit (CARPEDIEM; Bellco, Mirandola, Italy) was set up with a polysulfone hemofilter (0.25 m; cutoff 50… (More)
DOI: 10.1097/FTD.0000000000000320

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