Kinetics of 2-deoxyglucose transport in skeletal muscle: effects of insulin and contractions.

@article{Hansen1995KineticsO2,
  title={Kinetics of 2-deoxyglucose transport in skeletal muscle: effects of insulin and contractions.},
  author={Polly A Hansen and Eric Arthur Gulve and Jiaping Gao and J M Schluter and Mike M Mueckler and John O. Holloszy},
  journal={The American journal of physiology},
  year={1995},
  volume={268 1 Pt 1},
  pages={C30-5}
}
There is some controversy regarding whether insulin or contractile activity alters the affinity of skeletal muscle glucose transporters for glucose and its analogues. The effects of insulin and contractions on the kinetics of glucose transport were therefore reexamined in isolated rat skeletal muscles. Concentration-dependent rates of 2-deoxyglucose (2-DG) transport were measured in the absence or presence of insulin (2 mU/ml) in the epitrochlearis and split soleus muscles. The apparent half… CONTINUE READING