Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma.

@article{Monestiroli2001KineticsAV,
  title={Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma.},
  author={Silvia Monestiroli and Patrizia Mancuso and Alessandra Burlini and Giancarlo Pruneri and Chiara Dell'agnola and Alberto Gobbi and Giovanni Martinelli and Francesco Bertolini},
  journal={Cancer research},
  year={2001},
  volume={61 11},
  pages={4341-4}
}
Circulating endothelial cells (CECs) were evaluated by flow cytometry in immunodeficient mice bearing human lymphoma. A trend toward higher CEC values was observed on days 7 and 14 after transplant, and differences versus controls were highly significant on day 21 (P = 0.0061). A strong correlation was found between CEC and tumor volume (r, 0.942; P = 0.004) and between CEC and tumor-generated VEGF (r, 0.669; P = 0.02). In mice given cyclophosphamide, most of the circulating apoptotic cells… CONTINUE READING