Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitis.

@article{Garcia2001KineticsAT,
  title={Kinetics and thermodynamics of T cell receptor- autoantigen interactions in murine experimental autoimmune encephalomyelitis.},
  author={K Christopher Garcia and Caius G Radu and Jessica W-M Ho and Raimund J. Ober and E Sally Ward},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 12},
  pages={6818-23}
}
In the current study, cellular and molecular approaches have been used to analyze the biophysical nature of T cell receptor (TCR)-peptide MHC (pMHC) interactions for two autoreactive TCRs. These two TCRs recognize the N-terminal epitope of myelin basic protein (MBP1-11) bound to the MHC class II protein, I-A(u), and are associated with murine experimental autoimmune encephalomyelitis. Mice transgenic for the TCRs have been generated and characterized in other laboratories. These analyses… CONTINUE READING

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