Kinetics and thermodynamics of DNA polymerases with exonuclease proofreading.

Abstract

Kinetic theory and thermodynamics are applied to DNA polymerases with exonuclease activity, taking into account the dependence of the rates on the previously incorporated nucleotide. The replication fidelity is shown to increase significantly thanks to this dependence at the basis of the mechanism of exonuclease proofreading. In particular, this dependence… (More)
DOI: 10.1103/PhysRevE.93.042420

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