Corpus ID: 24874195

Kinetics and sodium independence of [3H]-tiazofurin blood to brain transport in the guinea pig.

@article{Redzic1996KineticsAS,
  title={Kinetics and sodium independence of [3H]-tiazofurin blood to brain transport in the guinea pig.},
  author={Zoran B. Redzic and Ivanka D. Markovic and Suzana Jovanovi{\'c} and Jovana M Ga{\vs}i{\'c} and D Mitrovi{\'c} and B V Zlokovics and Ljubisav Raki{\'c}},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={1996},
  volume={18 6},
  pages={
          413-8
        }
}
Tiazofurin is a nucleoside analog with potent antitumor activity. The objective of this study was to define the kinetic parameters of tiazofurin transport from blood into the guinea pig brain. The second aim was to define kinetic parameters of tiazofurin transport inhibition by adenosine (Ki and Kda), as well as whether tiazofurin blood-to-brain transport was performed in countertransport with Na+. In order to determine these parameters, the in situ method of perfusion of guinea pig brain was… Expand
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