Kinetics and phospholipid specificity of apolipoprotein N-acyltransferase.

@article{Hillmann2011KineticsAP,
  title={Kinetics and phospholipid specificity of apolipoprotein N-acyltransferase.},
  author={Falk Hillmann and Manuela Argentini and Nienke Buddelmeijer},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 32},
  pages={27936-46}
}
The enzyme apolipoprotein N-acyltransferase (Lnt) is an integral membrane protein that catalyzes the last step in the post-translational modification of bacterial lipoproteins. Lnt undergoes covalent modification in the presence of phospholipids resulting in a thioester acyl-enzyme intermediate. It then transfers the acyl chain to the α-amino group of the N-terminal diacylglyceryl-modified cysteine of apolipoprotein, leading to the formation of mature triacylated lipoprotein. To gain insight… CONTINUE READING

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