Kinetics and phospholipid specificity of apolipoprotein N-acyltransferase.

  title={Kinetics and phospholipid specificity of apolipoprotein N-acyltransferase.},
  author={Falk Hillmann and Manuela Argentini and Nienke Buddelmeijer},
  journal={The Journal of biological chemistry},
  volume={286 32},
The enzyme apolipoprotein N-acyltransferase (Lnt) is an integral membrane protein that catalyzes the last step in the post-translational modification of bacterial lipoproteins. Lnt undergoes covalent modification in the presence of phospholipids resulting in a thioester acyl-enzyme intermediate. It then transfers the acyl chain to the α-amino group of the N-terminal diacylglyceryl-modified cysteine of apolipoprotein, leading to the formation of mature triacylated lipoprotein. To gain insight… CONTINUE READING


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