Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondii.

@article{Jordan2009KineticsAP,
  title={Kinetics and phenotype of vaccine-induced CD8+ T-cell responses to Toxoplasma gondii.},
  author={Kimberly A. Jordan and Emma H Wilson and Elia D. Tait and Barbara A. Fox and D. v.d. S. Roos and David J Bzik and Florence S Dzierszinski and Christopher A Hunter},
  journal={Infection and immunity},
  year={2009},
  volume={77 9},
  pages={
          3894-901
        }
}
Multiple studies have established that the ability of CD8(+) T cells to act as cytolytic effectors and produce gamma interferon is important in mediating resistance to the intracellular parasite Toxoplasma gondii. To better understand the generation of the antigen-specific CD8(+) T-cell responses induced by T. gondii, mice were immunized with replication-deficient parasites that express the model antigen ovalbumin (OVA). Class I tetramers specific for SIINFEKL were used to track the OVA… CONTINUE READING

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