Kinetics and fate of IgA-IgG aggregates as a model of naturally occurring immune complexes in IgA nephropathy.

@article{Roccatello1992KineticsAF,
  title={Kinetics and fate of IgA-IgG aggregates as a model of naturally occurring immune complexes in IgA nephropathy.},
  author={Dario Roccatello and Giuseppe Picciotto and Roberto Ropolo and Rosanna Coppo and Giacomo Quattrocchio and Giovanni Cacace and Andrea R Molino and Antonio Amoroso and Massimo Baccega and Ciro Isidoro},
  journal={Laboratory investigation; a journal of technical methods and pathology},
  year={1992},
  volume={66 1},
  pages={86-95}
}
The characteristic granular IgA immunofluorescent pattern in the kidneys of IgA nephropathy patients is consistent with immune complex pathogenesis. The possibility of a delayed clearance of IgA-containing immune complexes from circulation in IgA nephropathy patients is still under discussion. Since pure IgA immune complexes are probably nonphlogistic, (in contrast to IgG-containing IgA immune complexes), the in vivo clearance of a mixture of heat-aggregated IgA/G purified from pooled human… CONTINUE READING