Kinetics and apoptotic profile of circulating endothelial cells as prognostic factors for induction treatment failure in newly diagnosed acute myeloid leukemia patients

@article{Wierzbowska2007KineticsAA,
  title={Kinetics and apoptotic profile of circulating endothelial cells as prognostic factors for induction treatment failure in newly diagnosed acute myeloid leukemia patients},
  author={Agnieszka Wierzbowska and Tadeusz Robak and Anna Krawczyńska and Agnieszka Pluta and Agata Wrzesień-Kuś and Barbara Cebula and Ewa Robak and Piotr Smolewski},
  journal={Annals of Hematology},
  year={2007},
  volume={87},
  pages={97-106}
}
The circulating endothelial cells (CEC) are proposed to be a noninvasive marker of angiogenesis. Recent data suggest that endothelial cells may enhance the survival and proliferation of leukemic blasts and mediate chemotherapy resistance in acute myeloid leukemia (AML). We analyzed CEC count by the four-color flow cytometry in AML and healthy subjects. We evaluated the kinetics of mature CEC, both resting (rCEC) and activated (aCEC), as well as progenitor (CEPC) and apoptotic CEC (CECAnnV+) in… CONTINUE READING
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