• DOI:10.1196/annals.1320.003
Corpus ID: 24803029

Kinetics, Pharmacokinetics, and Regulation of l‐Carnitine and Acetyl‐l‐carnitine Metabolism

@article{Rebouche2004KineticsPA,
  title={Kinetics, Pharmacokinetics, and Regulation of l‐Carnitine and Acetyl‐l‐carnitine Metabolism},
  author={C. Rebouche},
  journal={Annals of the New York Academy of Sciences},
  year={2004},
  volume={1033}
}

• C. Rebouche
• Published 2004
• Medicine, Chemistry
• Annals of the New York Academy of Sciences

Abstract: In mammals, the carnitine pool consists of nonesterified l‐carnitine and many acylcarnitine esters. Of these esters, acetyl‐l‐carnitine is quantitatively and functionally the most significant. Carnitine homeostasis is maintained by absorption from diet, a modest rate of synthesis, and efficient renal reabsorption. Dietary l‐carnitine is absorbed by active and passive transfer across enterocyte membranes. Bioavailability of dietary l‐carnitine is 54‐87% and is dependent on the amount… Expand