Kinetics, Pharmacokinetics, and Regulation of l‐Carnitine and Acetyl‐l‐carnitine Metabolism

  title={Kinetics, Pharmacokinetics, and Regulation of l‐Carnitine and Acetyl‐l‐carnitine Metabolism},
  author={Charles J. Rebouche},
  journal={Annals of the New York Academy of Sciences},
  • C. Rebouche
  • Published 1 November 2004
  • Biology, Medicine
  • Annals of the New York Academy of Sciences
Abstract: In mammals, the carnitine pool consists of nonesterified l‐carnitine and many acylcarnitine esters. Of these esters, acetyl‐l‐carnitine is quantitatively and functionally the most significant. Carnitine homeostasis is maintained by absorption from diet, a modest rate of synthesis, and efficient renal reabsorption. Dietary l‐carnitine is absorbed by active and passive transfer across enterocyte membranes. Bioavailability of dietary l‐carnitine is 54‐87% and is dependent on the amount… 

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Carnitine and Acylcarnitines

Previous research associated with the homeostasis and pharmaco-kinetics of L-carnitine and its esters are examined, and potential areas of future research are highlighted, to adequately characterize metabolic status.

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Pharmacokinetics of L-Carnitine

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Metabolic fate of dietary carnitine in human adults: identification and quantification of urinary and fecal metabolites.

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Metabolism and disposition of intravenously administered acetyl-L-carnitine in healthy volunteers

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L-Carnitine dissimilation in the gastrointestinal tract of the rat.

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