Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses

@inproceedings{Lenzi2014KineticVB,
  title={Kinetic variations between reverse transcriptases of viral protein X coding and noncoding lentiviruses},
  author={Gina M. Lenzi and Robert A. Domaoal and Dong-Hyun Kim and Raymond F Schinazi and Baek ki Kim},
  booktitle={Retrovirology},
  year={2014}
}
Host SAM domain and HD domain-containing protein 1 (SAMHD1) suppresses reverse transcription kinetics of HIV-1 in nondividing cells such as macrophages by hydrolyzing and nearly depleting cellular dNTPs, which are the substrates of viral reverse transcriptase (RT). However, unlike HIV-1, HIV-2 and SIVsm encode viral protein X (Vpx), which counteracts the dNTPase activity of SAMHD1 and elevates dNTP concentration, allowing the viruses to replicate under abundant dNTP conditions even in… CONTINUE READING