Kinetic theory of fibrillogenesis of amyloid beta-protein.

  title={Kinetic theory of fibrillogenesis of amyloid beta-protein.},
  author={Aleksey Lomakin and David B Teplow and Daniel A. Kirschner and George B. Benedek},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={94 15},
Prior quasielastic light scattering (QLS) studies of fibrillogenesis of synthetic amyloid beta-protein (Abeta)-(1-40) at low pH have suggested a kinetic model in which: (i) fibrillogenesis requires a nucleation step; (ii) nuclei are produced by Abeta micelles in addition to seeds initially present; and (iii) fibril elongation occurs by irreversible binding of Abeta monomers to the fibril ends. Here we present the full mathematical formulation of this model. We describe the temporal evolution of… CONTINUE READING


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