Kinetic study on the irreversible thermal denaturation of Schistosoma japonicum glutathione S-transferase.

@article{QuesadaSoriano2006KineticSO,
  title={Kinetic study on the irreversible thermal denaturation of Schistosoma japonicum glutathione S-transferase.},
  author={Indalecio Quesada-Soriano and Federico Garcia-Maroto and Lu{\'i}s Garc{\'i}a-Fuentes},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1764 5},
  pages={979-84}
}
The thermal unfolding pathway of the Schistosoma japonicum glutathione S-transferase (Sj26GST) was previously interpreted by applying equilibrium thermodynamics and a reversible two-state model (Kaplan et al., (1997) Protein Science, 6, 399-406), though weak support for this interpretation was provided. In our study, thermal denaturation of Sj26GST has been re-examined by differential scanning calorimetry in the pH range of 6.5-8.5 and in the presence of the substrate and S-hexylglutathione… CONTINUE READING

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