Kinetic study of anti-HIV drugs by thermal decomposition analysis

  title={Kinetic study of anti-HIV drugs by thermal decomposition analysis},
  author={B. D. L. Ferreira and B{\'a}rbara C.R. Araujo and Rita C. O. Sebasti{\~a}o and Maria Irene Yoshida and Wagner da Nova Mussel and S{\'i}lvia Lig{\'o}rio Fialho and Jamile Barbosa},
  journal={Journal of Thermal Analysis and Calorimetry},
Kinetic study by thermal decomposition of antiretroviral drugs, efavirenz (EFV) and lamivudine (3TC), usually present in the HIV cocktail, can be done by individual adjustment of the solid decomposition models. However, in some cases, unacceptable errors are found using this methodology. To circumvent this problem, here is proposed to use a multilayer perceptron neural network, with an appropriate algorithm, which constitutes a linearization of the network by setting weights between the input… 

Thermal decomposition kinetics of the antiparkinson drug “entacapone” under isothermal and non-isothermal conditions

The thermal decomposition kinetics of entacapone (ENT) have been investigated via thermogravimetric analysis under non-isothermal and isothermal conditions which provide useful stability information

Kinetic thermal decomposition studies of thalidomide under non-isothermal and isothermal conditions

Thermogravimetric analysis (TG) was used to investigate kinetic thermal decomposition process of thalidomide under non-isothermal and isothermal conditions. For the isothermal treatment, a

Investigation of the thermal stability of the antihypertensive drug nebivolol under different conditions: Experimental and computational analysis

The thermal decomposition of the third-generation beta-blocker nebivolol (NEB) was investigated using thermogravimetric analysis (TG) under isothermal and non-isothermal environments, revealing

Thermal behavior of ferulic acid employing isoconversional models and artificial neural network

Ferulic acid (FA) is a phenolic acid of plant kingdom presenting antioxidant activity, a fundamental pharmaceutical property. This property suggests FA can be used in cosmetic skin formulations as a

Artificial Neural Networks for Pyrolysis, Thermal Analysis, and Thermokinetic Studies: The Status Quo

A critical overview and summary of the available literature on applying ANNs in the field of pyrolysis, thermal analysis, and thermokinetic studies is given.

Thermal Stability of Amorphous Solid Dispersions

Evaluation of thermal stability of amorphous solid dispersion is perceived from the physicochemical perspective, from a kinetic (motions) and thermodynamic (energy) point of view, focusing on activation energy and fragility, as well all other relevant parameters for ASD design, with a glance on computational kinetic analysis of solid-state decomposition.

Thermal analysis of some novel pyrimidine derivatives

Some new pyrimidine derivatives have been synthesized and their decomposition characteristics have been studied by thermogravimetric and differential scanning calorimetric analysis. The thermal



Thermal behavior and decomposition kinetics of efavirenz under isothermal and non-isothermal conditions

Efavirenz (EFV), a non-nucleoside reverse transcriptase inhibitor, was approved for the treatment of human immunodeficiency virus type 1 infection (HIV-1), and it is used in the high activity

Kinetic Analysis of the Thermal Decomposition of Efavirenz and Compatibility Studies with Selected Excipients

SUMMARY. In the present work, the thermal decomposition of efavirenz (non-nucleoside reverse transcriptase inhibitor with a prolonged half-life) was studied using differential scanning calorimetry

Artificial neural network applied to solid state thermal decomposition

A multi-layer neural network is constructed to describe the thermal decomposition of rhodium acetate. Critical analysis of the residual, trained, interpolated and extrapolated errors, with the number

The evolution of three decades of antiretroviral therapy: challenges, triumphs and the promise of the future.

There is future promise, as an increased understanding of the immunopathogenesis of HIV and global public health initiatives are driving novel treatment approaches with goals to prevent, control and, ultimately, eradicate HIV.

Simulation study for generalized logistic function in thermal data modeling

This comprehensive simulation study allows to describe, analyze, and compare from a statistical standpoint the generalized logistic model with some well-known models used in the solid-state kinetics: power law, Avrami–Erofeev, and reaction order, and validate the performance of the generalizedLogistic model in a wide variety of cases where other methods can be applied.

Kinetics of Phase Change. I General Theory

The theory of the kinetics of phase change is developed with the experimentally supported assumptions that the new phase is nucleated by germ nuclei which already exist in the old phase, and whose

Neural Networks: A Comprehensive Foundation

Thorough, well-organized, and completely up to date, this book examines all the important aspects of this emerging technology, including the learning process, back-propagation learning, radial-basis function networks, self-organizing systems, modular networks, temporal processing and neurodynamics, and VLSI implementation of neural networks.

Thermal Analysis: Fundamentals and Applications to Polymer Science

Thermal Analysis. Differential Thermal Analysis and Differential Scanning Calorimetry. Calibration and Sample Preparation. Thermogravimetry. Applications of Thermal Analysis. Other Thermal Analysis