Kinetic studies of calcium binding to regulatory complexes from skeletal muscle.

@article{Rosenfeld1985KineticSO,
  title={Kinetic studies of calcium binding to regulatory complexes from skeletal muscle.},
  author={Steven S. Rosenfeld and Edwin W. Taylor},
  journal={The Journal of biological chemistry},
  year={1985},
  volume={260 1},
  pages={252-61}
}
The kinetic mechanism of the binding and release of calcium by troponin and by the complexes troponin: tropomyosin, troponin:tropomyosin:actin, and troponin (TN)-tropomyosin (TM)-actin:myosin subfraction 1 (SF-1) was investigated using troponin labeled on the TN-I subunit with the fluorophore 4-(N-iodoac etoxyethyl-N-methyl)-7-nitrobenz-2-oxa-1,3-diazole. The apparent association constant is five to 10 times smaller for TN:TM:actin compared to TN:TM or TN and saturation of actin sites with SF-1… CONTINUE READING

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