Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct.

@article{Conway2001KineticSO,
  title={Kinetic stabilization of the alpha-synuclein protofibril by a dopamine-alpha-synuclein adduct.},
  author={Kelly A. Conway and J C Rochet and Robert Marius Bieganski and P. T. Jun. Lansbury},
  journal={Science},
  year={2001},
  volume={294 5545},
  pages={
          1346-9
        }
}
The substantia nigra in Parkinson's disease (PD) is depleted of dopaminergic neurons and contains fibrillar Lewy bodies comprising primarily alpha-synuclein. We screened a library to identify drug-like molecules to probe the relation between neurodegeneration and alpha-synuclein fibrilization. All but one of 15 fibril inhibitors were catecholamines related to dopamine. The inhibitory activity of dopamine depended on its oxidative ligation to alpha-synuclein and was selective for the protofibril… CONTINUE READING
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