Kinetic role of helix caps in protein folding is context-dependent.

@article{Kapp2004KineticRO,
  title={Kinetic role of helix caps in protein folding is context-dependent.},
  author={Gregory T Kapp and Jane S. Richardson and Terrence G. Oas},
  journal={Biochemistry},
  year={2004},
  volume={43 13},
  pages={3814-23}
}
Secondary structure punctuation through specific backbone and side chain interactions at the beginning and end of alpha-helices has been proposed to play a key role in hierarchical protein folding mechanisms [Baldwin, R. L., and Rose, G. D. (1999) Trends Biochem. Sci. 24, 26-33; Presta, L. G., and Rose, G. D. (1988) Science 240, 1632-1641]. We have made site-specific substitutions in the N- and C-cap motifs of the 5-helix protein monomeric lambda repressor (lambda(6-85)) and have measured the… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

Use of protein engineering techniques to elucidate protein folding pathways.

Progress in molecular biology and translational science • 2008
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 62 references

The Protein Data Bank.

Nucleic acids research • 2000

Similar Papers

Loading similar papers…