Kinetic role of helix caps in protein folding is context-dependent.

  title={Kinetic role of helix caps in protein folding is context-dependent.},
  author={Gregory T Kapp and Jane S. Richardson and Terrence G. Oas},
  volume={43 13},
Secondary structure punctuation through specific backbone and side chain interactions at the beginning and end of alpha-helices has been proposed to play a key role in hierarchical protein folding mechanisms [Baldwin, R. L., and Rose, G. D. (1999) Trends Biochem. Sci. 24, 26-33; Presta, L. G., and Rose, G. D. (1988) Science 240, 1632-1641]. We have made site-specific substitutions in the N- and C-cap motifs of the 5-helix protein monomeric lambda repressor (lambda(6-85)) and have measured the… CONTINUE READING

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The Protein Data Bank.

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