Kinetic resolution of allylic alcohols using a chiral phosphine catalyst.

@article{Vedejs2001KineticRO,
  title={Kinetic resolution of allylic alcohols using a chiral phosphine catalyst.},
  author={Edwin Vedejs and James A Mackay},
  journal={Organic letters},
  year={2001},
  volume={3 4},
  pages={535-6}
}
[reaction: see text] The kinetic resolution of racemic allylic alcohols 3, 6, and 12--17 has been explored using the PBO catalyst 7 for activation of isobutyric anhydride. Trisubstituted allylic alcohols (12--15; 17) are the best substrates and react with an enantioselectivity of s = 32--82 at -40 degrees C.