Kinetic properties of placental aminopeptidase A: N-terminal degradation of angiotensin II.

Abstract

Purified placental aminopeptidase A cleaved N-terminal aspartic acid of Angiotensin II, and it was inhibited by amastatin. Amastatin and various angiotensin analogs having N-terminal dicarboxylic acid were potent inhibitors of the enzyme. Kinetic analysis indicated that amastatin, angiotensin II, the N-terminal tripeptide of angiotensin II, and aspartic… (More)

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