Kinetic profile of overall elimination of 5-methyltetrahydropteroylglutamate in rats.


The in vivo biliary and urinary excretion kinetics of 5-methyltetrahydropteroylglutamate (5-CH3-H4PteGlu) were studied in rats. During infusion at various rates (48-965 nmol ⋅ h-1 ⋅ kg-1), the total body clearance (CLtotal) of 5-CH3-H4PteGlu could be attributed almost entirely to the sum of the biliary and urinary (CLurine,p) excretion clearances. After a 4… (More)
DOI: 10.1152/ajpendo.1999.276.3.E580


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