Kinetic parameters of desulfuration and dearylation of parathion and chlorpyrifos by rat liver microsomes.

@article{Ma1994KineticPO,
  title={Kinetic parameters of desulfuration and dearylation of parathion and chlorpyrifos by rat liver microsomes.},
  author={T. Ma and J. Chambers},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1994},
  volume={32 8},
  pages={
          763-7
        }
}
  • T. Ma, J. Chambers
  • Published 1994
  • Biology, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Parathion and chlorpyrifos are phosphorothionate insecticides, but parathion is substantially more toxic than chlorpyrifos to rats, and both are more toxic to females than to males. A kinetic analysis of cytochrome P-450 mediated desulfuration (activation) and dearylation (detoxication) of the two insecticides indicated that rat hepatic microsomes have a higher capacity to activate and a lower capacity to detoxify parathion than chlorpyrifos; these capacities correspond to their acute toxicity… Expand
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An age-dependent physiologically based pharmacokinetic/pharmacodynamic model for the organophosphorus insecticide chlorpyrifos in the preweanling rat.
Kinetic parameters of OPT pesticide desulfuration by c-DNA expressed human CYPs.
The Human Metabolism of Organophosphorothionate Pesticides: Consequences for Toxicological Risk Assessment
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