Kinetic models reveal the in vivo mechanisms of mutagenesis in microbes and man.

@article{Wright2013KineticMR,
  title={Kinetic models reveal the in vivo mechanisms of mutagenesis in microbes and man.},
  author={Barbara E. Wright and Karen H. Schmidt and Michael Minnick},
  journal={Mutation research},
  year={2013},
  volume={752 2},
  pages={129-37}
}
This review summarizes the evidence indicating that mutagenic mechanisms in vivo are essentially the same in all living cells. Unique metabolic reactions to a particular environmental stress apparently target specific genes for increased rates of transcription and mutation, resulting in higher mutation rates for those genes most likely to solve the problem. Kinetic models which have demonstrated predictive value are described and are shown to simulate mutagenesis in vivo in Escherichia coli… CONTINUE READING
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