Kinetic modeling of storage effects on biomarkers related to B vitamin status and one-carbon metabolism.

@article{Hustad2012KineticMO,
  title={Kinetic modeling of storage effects on biomarkers related to B vitamin status and one-carbon metabolism.},
  author={Steinar Hustad and Simone J P M Eussen and \Oivind Midttun and Arve Ulvik and Puck M van de Kant and Lars M\orkrid and Randi Elin Gislefoss and Per Magne Ueland},
  journal={Clinical chemistry},
  year={2012},
  volume={58 2},
  pages={402-10}
}
BACKGROUND Biomarkers and metabolites related to B vitamin function and one-carbon metabolism have been studied as predictors of chronic diseases in studies based on samples stored in biobanks. For most biomarkers, stability data are lacking or fragmentary. METHODS Degradation and accumulation kinetics of 32 biomarkers were determined at 23 °C in serum and plasma (EDTA, heparin, and citrate) collected from 16 individuals and stored for up to 8 days. In frozen serum (-25 °C), stability was… CONTINUE READING
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