Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assembly.

@article{Ibrahimi2004KineticMF,
  title={Kinetic model for FGF, FGFR, and proteoglycan signal transduction complex assembly.},
  author={Omar A. Ibrahimi and Fuming Zhang and Sybil C. L. Hrstka and Moosa Mohammadi and Robert J. Linhardt},
  journal={Biochemistry},
  year={2004},
  volume={43 16},
  pages={
          4724-30
        }
}
The current working model for fibroblast growth factor receptor (FGFR) dimerization and activation requires the assembly of a ternary complex of fibroblast growth factor (FGF), FGFR, and heparin or heparan sulfate proteoglycan (HSPG) on the plasma membrane. The recent FGF2-FGFR1-heparin crystal structure provides a detailed but static view of the FGF-FGFR-heparin complex. However, the kinetics of ternary complex assembly has yet to be investigated. Here, we characterize FGF2, FGFR1, and heparin… CONTINUE READING

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