Kinetic intermediates in the folding of gaseous protein ions characterized by electron capture dissociation mass spectrometry.

@article{Horn2001KineticII,
  title={Kinetic intermediates in the folding of gaseous protein ions characterized by electron capture dissociation mass spectrometry.},
  author={David Micha Horn and Kathrin Breuker and Arthur J. Frank and Fred W. McLafferty},
  journal={Journal of the American Chemical Society},
  year={2001},
  volume={123 40},
  pages={9792-9}
}
Alternative mechanisms propose that protein folding in solution proceeds either through specific obligate intermediates or by a multiplicity of routes in a "folding funnel". These questions are examined in the gas phase by using a new method that provides details of the noncovalent binding of solvent-free protein ions. Capture of an electron by a multiply charged cation causes immediate dissociation (ECD) of a backbone bond, but with negligible excitation of noncovalent bonds; thus ECD of a… CONTINUE READING
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