Kinetic framework of spindle assembly checkpoint signalling

  title={Kinetic framework of spindle assembly checkpoint signalling},
  author={Amalie E. Dick and Daniel W Gerlich},
  journal={Nature Cell Biology},
The mitotic spindle assembly checkpoint (SAC) delays anaphase onset until all chromosomes have attached to both spindle poles. Here, we investigated SAC signalling kinetics in response to acute detachment of individual chromosomes using laser microsurgery. Most detached chromosomes delayed anaphase until they had realigned to the metaphase plate. A substantial fraction of cells, however, entered anaphase in the presence of unaligned chromosomes. We identify two mechanisms by which cells can… CONTINUE READING
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