Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum.

@article{Cobbold2013KineticFP,
  title={Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum.},
  author={Simon A. Cobbold and Ashley M. Vaughan and Ian A. Lewis and Heather J. Painter and Nelly Camargo and David Perlman and Matthew E. Fishbaugher and Julie Healer and Alan F Cowman and Stefan H. I. Kappe and Manuel Llin{\'a}s},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 51},
  pages={36338-50}
}
The malaria parasite Plasmodium falciparum depends on glucose to meet its energy requirements during blood-stage development. Although glycolysis is one of the best understood pathways in the parasite, it is unclear if glucose metabolism appreciably contributes to the acetyl-CoA pools required for tricarboxylic acid metabolism (TCA) cycle and fatty acid biosynthesis. P. falciparum possesses a pyruvate dehydrogenase (PDH) complex that is localized to the apicoplast, a specialized quadruple… CONTINUE READING

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Atypical lipid composition in the purified relict plastid (apicoplast) of malaria parasites.

Proceedings of the National Academy of Sciences of the United States of America • 2013
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