Kinetic experiments on the synergistic effect of NADH on microsomal drug oxidation.

@article{Netter1974KineticEO,
  title={Kinetic experiments on the synergistic effect of NADH on microsomal drug oxidation.},
  author={K. Netter and H. Illing},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1974},
  volume={4 9},
  pages={
          549-61
        }
}
  • K. Netter, H. Illing
  • Published 1974
  • Chemistry, Medicine
  • Xenobiotica; the fate of foreign compounds in biological systems
  • Abstract1. The synergistic effect of NADH on the NADPH-dependent mixed function oxidation of p-nitroanisole and hexobarbital can be measured both photometrically and by following the substrate-induced oxygen consumption. The increase in reaction rate is about 50% and lasts as long as NADH is present in the microsomal suspension.2. The oxidation of added NADH is increased by hexobarbital, ethylmorphine and SKF 525-A. Lineweaver-Burk transformation of the NADH oxidation rates yields straight… CONTINUE READING
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